Order RSDLImportant Safety Information

DEFEND AGAINST MULTIPLE THREATS

RSDL REDUCED TOXIC EFFECTS OF A NERVE AGENT, ESPECIALLY WITHIN FIRST HOUR AFTER EXPOSURE

Whether initiated early or delayed, RSDL decontamination significantly reduced V-series nerve agent (VX) penetration of human skin1,*

Grouped bar chart: degree of VX decontamination achieved with RSDL by exposure time. The decontamination factor is highest when RSDL is applied 5 minutes after exposure and falls sharply as the exposure time before decontamination lengthens to 120 minutes. Every plotted value is available below under View chart data.
VX exposure time before decontamination (min)

*Early decontamination was measured as 5–10 minutes after exposure; delayed decontamination was between 30 and 60 minutes post-exposure.1

†P<0.001, ‡P<0.01, §P<0.05 for the comparison of the cumulative amount of VX in RSDL-treated skin at the given time point with the cumulative amount of VX in untreated skin.1

RSDL DEMONSTRATED PROTECTION AGAINST NERVE AGENTS IN ANIMAL STUDIES

Using the protective ratio parameter, RSDL was shown to be the most effective decontaminant against nerve agents when compared with water, bleach, and dry sorbents2,3,‖,¶

Grouped bar chart: protective ratio values for four decontamination products against soman (GD) and V-series nerve agent (VX). RSDL has the highest protective ratio against both agents. Every plotted value is available below under View chart data.

‖The protective ratio is defined as the median lethal dose (defined as the LD50) in the treatment group divided by the LD50 in the non-treated positive control group.2

Dry sorbents=M291 SDK.

#Protective ratio values for the decontamination products in a guinea pig model.2,3

SDK=Skin Decontamination Kit.

RSDL DEMONSTRATED SMALLER LESION SIZE AFTER MUSTARD AGENT (HD) EXPOSURE IN ANIMAL STUDIES

The efficacy of RSDL decontamination against a mustard agent was evaluated in comparison with water and dry sorbents, based on the analysis of lesion areas4,††

Nested-area figure, not to scale: mean lesion area 24 hours after HD exposure. Four squares share a bottom-left corner — the area exposed to HD, then the lesion area after treatment with water, with M291 SDK and, smallest, with RSDL. Every labelled value is available below under View chart data.

††Dry sorbents=M291 SDK.

‡‡Approximately 2-minute HD exposures in a rabbit model.4

§§The lesion area was calculated as an ellipsoid: Area = πlw/4, where l was the length (mm) and w was the width (mm) of the lesion.4

SD=standard deviation.

Important Safety Information

Intended Use

The RSDL® (Reactive Skin Decontamination Lotion) kit is intended to remove and/or neutralize chemical warfare agents (CWA) and T-2 toxin from the skin. For external use only by trained individuals. Use only if chemical warfare agent exposure is suspected.

CAUTION: Use only as directed. RSDL® is not a substitute for proper protective breathing devices and garments. Not for use prior to exposure (i.e., prophylactic use) or whole-body decontamination. Allow RSDL® to remain on the skin for at least two minutes. An RSDL® ingredient is absorbed through the skin which may cause adverse effects. Avoid leaving on the skin for long periods. Avoid contact with the eyes and mucous membranes and rinse eyes thoroughly if contact occurs. Remove RSDL® with soap and water when conditions permit. Keep out of reach of children.

WARNING: Fire Hazard. Combustion may occur upon contact with strong oxidizing chemicals (e.g., HTH [calcium hypochlorite], Super Tropical Bleach). Do not discard used RSDL® components into strong oxidizing chemicals or their containers.

The SAFETY Act (“the Act”) provides incentives for the development and deployment of anti-terrorism technologies by creating a system of “risk management” and a system of “litigation management.” The purpose of the Act is to ensure that the threat of liability does not deter potential manufacturers or Sellers of anti-terrorism technologies from developing, commercializing, and deploying technologies that could significantly reduce the risks or mitigate the effects of large-scale terrorist events. Thus, the Act creates certain liability limitations for “claims arising out of, relating to or resulting from an Act of Terrorism” where Qualified Anti-Terrorism Technologies have been deployed. The Act does not limit liability for harms caused by anti-terrorism technologies when no Act of Terrorism has occurred.

Suspected Adverse Events, Product Complaints & Medical Information:
serbmedinfo@serb.com / 877-377-3784

For more information on RSDL including order inquiries, please contact:
SERB MEDICAL SOLUTIONS INC. / 300 Four Falls Corporate Center, 300 Conshohocken State Road, Suite 300, West Conshohocken, PA 19428-3820
RSDL@serb.com

References
  1. Thors L, Lindberg S, Johansson S, et al. RSDL decontamination of human skin contaminated with the nerve agent VX. Toxicol Lett. 2017;269:47-54.
  2. Schwartz MD, Hurst CG, Kirk MA, Reedy SJD, Braue EH Jr. Reactive Skin Decontamination Lotion (RSDL) for the decontamination of chemical warfare agent (CWA) dermal exposure. Curr Pharm Biotechnol. 2012;13(10):1971-1979.
  3. Hanssen KA, Doxzon BF, Lumpkin HL, Clarkson E, Braue EH Jr. Evaluation of Decontamination Systems Challenged With Nerve Agents. US Army Medical Research Institute of Chemical Defense, US Department of War; 2006.
  4. Snider TH, Hayes TL, Jarvis RJ II, Matthews MC, Estep JE. A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program on Module 1 of Task 0008, Assessment of RSDL as a Decontaminant Against VX and HD: Efficacy, Equivalence to M291 Skin Decontamination Kit, and Compatibility with Fielded Materials. Battelle; 2001.